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Caltech Alumni Luncheon

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Location: Baylands Café
1875 Embarcadero Rd.
Palo Alto, CA 94303
Description: Join us as we thank Chris Spence and Yu Cao for last month’s very interesting discussion, “The Future of Lithography—How Far Could We Go?”

This month, Robert Waymouth will discuss, “Delivery: A Major Challenge For Gene Editing and Gene Therapy”.

With the advancement of new gene editing strategies (CRISPR/Cas9, TALEN), new tools and therapies are emerging, but the delivery of genes to the appropriate cells and tissues in-vivo remains a formidable challenge. Just like packaging, delivery logistics is extremely important.

In this talk, I will describe our recent scientific breakthroughs to precisely deliver genes into living animals. Functional delivery of messenger RNA (mRNA) in-vivo is key to implementing potentially transformative strategies for vaccination, protein replacement therapy and genome editing, as mRNA carries the instructions for cells to generate their own therapeutics.

We have developed an expedient synthesis of a new, tunable and effective class of synthetic biodegradable materials for mRNA delivery: charge-altering releasable transporters (CARTs). CARTs are structurally unique and operate through an unprecedented mechanism, serving initially as oligo(α-amino ester) cations that complex, protect and deliver mRNA, and then change physical properties through a degradative, charge-neutralizing intramolecular rearrangement, leading to intracellular release of functional mRNA and highly efficient protein expression. CART delivery works for siRNA, mRNA, pDNA, LNA, and coformulations involving CRISPR/Cas 9.

Significantly, CART delivery is effective against a variety of cell types and can be targeted to various organs. This technology has been used to protect mice from cancer, to cure established tumors in mice and to effect gene editing by both knock in and knock out of protein function.

Robert is the Robert Eckles Swain Professor of Chemistry at Stanford University. He received B.S. in Mathematics and B.A. in Chemistry from Washington and Lee University and his Ph.D. in Chemistry at the Caltech in 1987 with Professor R.H. Grubbs. He was a postdoctoral fellow with the late Professor Piero Pino at the ETH in Zurich in 1987 and joined the faculty at Stanford as an Assistant Professor in 1988. He received the Alan T. Waterman Award from the NSF in 1996, the Cooperative Research Award in Polymer Science in 2009, and EPA’s Presidential Green Chemistry Challenge Award in 2012 with Dr. James Hedrick.

He has won several university teaching awards, including the Walter J. Gores Award, the Phi Beta Kappa Teaching Award, and is currently a Bass Fellow in Undergraduate Education.

His research interests are at the interface of Inorganic, Organic and Polymer Chemistry, in particular the development of new concepts in catalysis for the selective synthesis of both macromolecules and fine chemicals. Particular areas of interest include catalytic polymerization reactions, selective oxidation catalysis, the development of organocatalytic polymerization strategies, and the design of functional macromolecules for applications in biology and medicine.

Fee: $22.00, including lunch, tax, and gratuity | $5.00 for those not eating the buffet (Please state “not eating” after your name when you register)

Date And Time

2018-12-20 @ 11:30 AM
@ 02:00 PM


1875 Embarcadero Rd. Palo Alto, CA 94303, 1875 Embarcadero Rd. Palo Alto, CA 94303


Baylands Café

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